I got Locomotion working on my machine, but that pretty much works with anything and is enough to keep me happy. I've not had much luck with other games either, but thats only because this laptop is ancient.
You can look up game compatibility and user experiences with wine on their application database. http://appdb.winehq.org/
Well, if you want to give a good MMORPG called The Mana World a spin or want to play a couple of great games through emulation, then http://www.trixarian.za.net/?Projects:SliTaz might be useful.
I like playing old Lucas Arts Adventure games through ScummVM and Japanese RPG classics like Final Fantasy 6 on emulators like ZSNES.
Also for those interested, I got an older copy OpenTTD to work with SliTaz @ http://www.box.net/shared/z0f8957g2i - it's the 0.6.2 version, so you'll need the original Transport Tycoon Deluxe files in ~/.openttd/data/ for it to work and it may also require the renaming of certain files like SAMPLE.CAT to sample.cat
Because, on mine, the plugin installs but after having restart Firefox as needed, the same message requires ton install again the plugin ... and so on ..
When I decide to refuse to re-install the plugin, before starting a game; I have this message
" You are downloading required data and must let it finish before you can join an online match. "